Systemic absorption of Soframycin after subconjunctival injection.

Unusual complication associated with a subconjunctival injection of Soframycin.

Effect of subconjunctivally injected, liposome-bound, low-molecular-weight heparin on the absorption rate of subconjunctival hemorrhage in rabbits.

PURPOSE To investigate the effect of subconjunctival injection of liposome-bound, low-molecular-weight heparin (LMWH) on the absorption rate of subconjunctival hemorrhages. METHODS Subconjunctival hemorrhages were induced in both eyes of 30 rabbits by the subconjunctival injection of 0.1 mL of autologous blood from auricular marginal veins. After 8 hours, randomized subconjunctival injections...

Intracameral injections of framycetin sulphate (Soframycin) in fulminating corneal infections. A clinical trial.

The impermeability of the blood-aqueous barrier to certain antibiotics precludes their use in intraocular infections, and it is very difficult to identify the causative organism if laboratory facilities are not available. With these limitations in view we embarked upon a blanket trial of framycetin sulphate (Soframycin eye drops o 5 per cent.) by intracameral injection in nine cases of intracta...

Subconjunctival administration of soframycin in the treatment of corneal infections.

THE properties of Soframycin, an antibiotic extracted from the mould Streptomyces decaris, were first evaluated by Massenat-Derouche (1954). Its properties in relation to the eye and its effect upon experimentally produced corneal infections were described by Ainslie and Henderson (1958). It was found to be especially effective against staphylococcal infections but was active too against many G...

The difficulty of determining the route of intraocular penetration of gentamicin after subconjunctival injection in the rabbit.

In small animals such as the rabbit the ratio of eye size to body size is much larger than it is in humans. Accordingly, periocular injection of antibodies in this animal model results in significantly higher serum concentrations than does a comparable does in a human. To assess the effect of the systemic drug component on ocular penetration, we compared the levels of gentamicin in ocular tissu...